By David J. Goldstein, William Z. Potter, Domenic A. Ciraulo (auth.), Domenic A. Ciraulo, Richard Irwin Shader (eds.)
Comprehensive and state of the art, the second one version of Pharmacotherapy of melancholy deals significant revisions of each bankruptcy and the addition of latest chapters via specialist participants. the 1st bankruptcy reports the neurobiology of melancholy, which lays the basis for figuring out the mechanisms of motion of antidepressants. within the subsequent bankruptcy, a overview of the final ideas guiding the prognosis and drugs therapy of unipolar melancholy is equipped. The scientific pharmacology of antidepressants is reviewed in a few element, supplemented via tables that offer details on dosing, symptoms, and metabolism. Augmentation concepts are reviewed, together with using non-traditional brokers. The chapters that persist with subsequent deal with using antidepressants in specified populations, resembling the aged and depressed people with psychosis, bipolar disease, substance abuse, and submit nerve-racking pressure affliction. The complicated matters related to the analysis and therapy of melancholy while pregnant is punctiliously reviewed in bankruptcy eight and offers a synthesis of the clinical literature within the sector, one who is famous for contradictory and debatable findings, in addition to directions for prescribing. the subsequent bankruptcy then offers an summary of the therapy of melancholy within the pediatric inhabitants, highlighting scientific issues comparable to suicide threat. The e-book concludes with chapters on the interface of medication and psychiatry within the therapy of temper problems: coping with melancholy in basic care settings and melancholy linked to clinical health problems. the phenomenal clinician-scientists who've contributed to this quantity are all leaders of their fields and symbolize a extensive spectrum of popular associations. A well timed contribution to the literature, The Pharmacotherapy of melancholy, moment variation, bargains busy clinicians from many disciplines a robust medical starting place that seamlessly transitions into useful thoughts for scientific perform. the result's one other gold-standard advisor to the secure and potent use of the most recent antidepressant medications.
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Extra resources for Pharmacotherapy of Depression
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The clinical literature suggests that approximately 7–10% of Caucasians are slow metabolizers through CYP2D6 and toxic levels of imipramine, desipramine, and other agents metabolized via this pathway may result from standard therapeutic doses. Poor metabolizers of drugs that utilize the CYP2C19 may also develop adverse effects at standard doses. Although the SSRI have a large therapeutic index, so that most patients are able to tolerate wide fluctuations in plasma levels due to pharmacokinetic interactions, several are potent inhibitors of the CYP450 system (fluoxetine, fluvoxamine, paroxetine) and can affect toxicity of coadministered drugs that are metabolized via this system.