By N. R. Farnsworth, A. S. Bingel (auth.), Prof. Dr. H. Wagner, Dr. P. Wolff (eds.)
The incontrovertible fact that, of the nearly 600,000 plant species latest on this planet, just some five % were in particular investigated chemically or pharmacologi cally, is a problem to chemists spezializing in na tural components and to pharmacologists. In view of the constrained variety of examine capacities and the ever diminishing monetary capability, this problem can merely be met if, including an development and refinement of tools of study, medicinal plant study is performed on a broader interdisciplinary foundation, with related, scientifically famous screening tools, and whether it is larger coordinated, with higher use of recent documentation capacity. it's hence helpful sooner or later to pay attention in particular on tasks resulting in the advance of recent medicinal prepara tions. The plenary lectures carry within the current symposium of the first foreign Congress for examine on Medi cinal crops replicate those efforts and developments. even as they supply a survey of a few of the fields of medicinal plant learn that are at the moment so much real and so much intensively researched. they vary from plant screening, isolation and constitution eluci dation of latest ideas, to the therapeutical opti mization of a usual product. The lectures given at this congress convey sincerely the need, as well as nationwide phytochemical so cieties, for a important overseas business enterprise, during which all lively medicinal plant researchers on the earth are integrated. Their goal may be to supply the impulse for extra optimum, rational study, aimed toward the answer of particular projects.
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Additional resources for New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity: Proceedings of the First International Congress on Medicinal Plant Research, Section A, held at the University of Munich, Germany, September 6–10, 1976
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It requires the equivalent of one working day for one technician to test one sample. 25 % agar is the specified vehicle for dosing). 0 g of crude material is generally necessary to complete the screening procedure. g. its use by the Amazon Nat,ural Products Drug Company in Iquitos, Peru). , 1961). The data from a single study can be handled as a series of traditional analysis-of-variance assays or as a single multivariate analysis. While such quantitative studies are clearly publishable, the goal of the hippocratic screen really is not quantitation but qualitative orientation -- to guide the pharmacologist and toxicologist in launching more specific studies (secondary and tertiary evaluations) and to guide the pharmacognosist in extraction/isolation procedures.
If prepared correctly, this vehicle lacks viscosity, yet has excellent suspending capacity for solvent-free extractives and for finely divided (> 200 mesh) plant materials. This vehicle is virtually nontoxic intraperitoneally for rats. A constant dosage volume of 5 ml/ kg is specified for all dose levels so there are no volume effects in regard to the onset of drug-induced symptomatology. In the rat, the presence of up to 10 % of tannins in crude drug material has been shown not to affect the response patterns -- even in the case of tanninprecipitated alkaloids (Malone and Robichaud, 1962).