By Toshifusa Nakajima (auth.), Toshifusa Nakajima M.D., Ph.D., Toshiharu Yamaguchi M.D., Ph.D. (eds.)
Recent scientific trials of adjuvant remedy for gastric melanoma in Japan have proven greater survival advantages, however the effects were thought of arguable and feature been considered with a few skepticism within the West. in the past, the efforts of eastern surgical oncologists in multimodality treatment haven't been totally understood simply because they've got now not been correctly stated in English. This quantity now provides the adventure and services of jap surgeons who make the most of preoperative or intraoperative chemotherapy, or a mixture of systemic and neighborhood chemotherapy. Their accumulated paintings offers worthy perception within the eastern standpoint and good fortune in treating gastric melanoma. integrated within the appendix is an in depth tabular research of the gastric melanoma database on the melanoma Institute clinic of Tokyo. most likely the biggest such database on the earth from a unmarried establishment, the analyses current the cutting-edge in remedy of gastric cancer.
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Additional info for Multimodality Therapy for Gastric Cancer: Appendix: Database of the Cancer Institute Hospital
V. o. v. e. o. v. Surgery alone 69 76 38 77 MMC, mitomycin C; 5-FU, 5-fluorouracil; CA, cytosine arabinoside; FT207: a masked compound of 5-FU; OK, piccibanil, streptococcal preparation (immunomodulator); CPM, cyclophosphoamide; PSK, protein-bound polysaccharide (immunomodulator); CIH, Cancer Institute Hospital, Tokyo; POD, postoperative day. Table 3 and Fig. 1. The summary odds ratio in Fig. 1 was calculated by the mothod of DerSimonian-Laird. ), yielded statistically significant survival benefit.
Chemotherapy 42:220-226 13. Neri B, deLeonardis V, Romano S, Andreoli F, Pernice LM, Bruno K, Borrelli D, Valeri A, Fabbroni S, Intini C, Cini G (1996) Adjuvant chemotherapy after gastric resection in node-positive cancer patients: a multicenter randomized study. Br J Cancer 73:549-552 14. Krook JE, O'Connell MJ, Wieand HS, Beart RW Jr, Leigh JE, Kugler JW, Foley JF, Pfeifle DM, Tuito DI (1991) A prospective randomized evaluation of intensive course 5-fluorouracil plus doxorubicin as surgical adjuvant chemotherapy for resected gastric cancer.
Based on autopsies of 54 patients, peritoneal and liver metastases were found with equal frequencies in both arms of the protocol. The Austrian Working Group for Surgical Oncology (AWGSO) utilized mitomycin C bound to 375mg of carboadsorbens administered intraperitoneally (IP) before wound closure after gastrectomy in 46 patients, comparing their results to those of 45 patients who did not receive IP . The total incidence of postoperative complications was 35% in the treatment group but only 16% among controls; and 60day mortality was higher, 11% versus 2%.