Download Hepatitis C Virus: From Molecular Virology to Antiviral by Peter Simmonds (auth.), Ralf Bartenschlager (eds.) PDF

By Peter Simmonds (auth.), Ralf Bartenschlager (eds.)

Hepatitis C virus (HCV), an incredible causative agent of persistent liver ailment, is unfold during the global and round one hundred seventy million individuals are again and again contaminated. during this quantity, world-leading specialists within the box of HCV examine have compiled the latest clinical advances to supply a entire and intensely well timed evaluate of many of the aspects of HCV. The publication starts off with a dialogue of the prospective foundation of HCV and its unfold one of the human inhabitants. the focal point of the next chapters is on on hand mobilephone tradition and in vivo types sooner than transferring to the molecular and mobile rules underlying the viral replication cycle. those chapters are complemented through insightful descriptions of the innate and adaptive immune responses to HCV in addition to the virus-associated pathogenesis. eventually, the advance of antiviral cures, that is heavily associated with development in uncomplicated examine, and the implementation of these remedies into current and destiny day-by-day scientific perform are highlighted.

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Extra resources for Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

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2009). Besides this, the observation that REMs can interfere with virus production in Con1 genomes provided a simple explanation why the adapted Con1 genomes unlike the wild type were noninfectious in Chimpanzee or reverted back to the wild-type sequence (Bukh et al. 2002). It is, however, important to stress here that REMs do not necessarily lead to inactivation of virus production. , the K1846T exchange within the NS4B protein of Con1) that does not interfere with production of infectious particles (Pietschmann et al.

5 and Huh-7-Lunet/CD81 cells are two examples that support high levels of RNA replication and infection (Blight et al. 2002; Koutsoudakis et al. 2007).  2 Primary cells and cell lines supporting HCV replication. The origin of human and murine cell lines permissive for HCV replication is given. Cells reported to support the complete HCV replication cycle including cell entry, RNA replication, and de novo production of infectious viral progeny are marked by an asterisk. Note that permissiveness between cells varies greatly and is generally highest in Huh-7-derived cell clones.

J Virol 82(12):5715–5724 Cell Culture Systems for Hepatitis C Virus 41 Akazawa D, Date T et al (2007) CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection. J Virol 81(10):5036–5045 Ali S, Pellerin C et al (2004) Hepatitis C virus subgenomic replicons in the human embryonic kidney 293 cell line. J Virol 78(1):491–501 Appel N, Herian U et al (2005) Efficient rescue of hepatitis C virus RNA replication by transcomplementation with nonstructural protein 5A.

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