By I. M. Verma, R. K. Naviaux, Y. Dai (auth.), Prof. M. D. Fred H. Gage, Ph. D. Yves Christen (eds.)
Gene move know-how is a strong device for expanding our understandingof mind features. it's also the foundation of gene treatment, that's now technically attainable for the correction of many human ailments, together with a number of problems of the anxious (and muscular) method corresponding to Alzheimer's illness, Parkinson's ailment, and dystrophy. This volume,which includes the lawsuits of a symposium of the Fondation Ipsen, presents a special view of the state-of-the-art on varied transgenes, vectors, objective cells, and scientific purposes regarding the apprehensive procedure.
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Additional info for Gene Transfer and Therapy in the Nervous System
However, in these recent studies, it is not yet completely clear that the wild-type RB gene product continues to be expressed in the tumor cells or whether deleted or otherwise mutated forms of RB had been selected in the newly developed tumors. Much work is still required to characterize these results fully. A further test of the restoration of heterozygosity model has been provided by Vogelstein and his colleagues, who have demonstrated that the in vitro growth of colon carcinoma cells can be slowed by introducing genes encoding a normal copy of DCC, a gene that constitutes one of the earliest targets in the development of colon carcinoma.
In addition, the neurotransmitter and neuropeptide phenotype can be specified by the identity of the target that the innervating axons contact. Cutaneous nerves in the adult rat that normally contain substance P lose this peptide when made to innervate muscle; conversely, when muscle afferents innervate skin, they express substance P (McMahon and Gibson 1987). During normal development in vivo, sympathetic neurons alter their transmitter and peptide phenotype upon contact with certain target cells, such as the sweat glands of the rat footpad (Landis 1990).
Development, regeneration and plasticity of the autonomic nervous system. Elsevier, London, pp 231-265 Patterson PH, Niijima K, Chalmero GA, Peterson DA, Fisher LT, Gage FH (1992) Adrenal chromaffin cell co-grafted with NGF-secreting fibroblasts. Restorative Neurol Neurosci 4:2704 Patterson PH (1992) The emerging neuropoietic cytokine family: first CDFfLIF, CNTF and IL-6, next ONC, MGF and GCSF? Curr Opinion Neurobiol 2:94-97 Patterson PH (1992) Instructive neuronal differentiation factors. ) Neurotrophic factors.