By Christian Lattermann, Freddie H. Fu (auth.), Johnny Huard, Freddie H. Fu (eds.)
This e-book has been written based on the various physicians and scien tists engaged on the advance of organic ways to delivering cures for lots of orthopaedic problems in addition to to enhancing the therapeutic of many tissues of the musculoskeletal procedure. the 1st target of this e-book is to make the language suitable among the bench scientist and the clinician operating in orthopaedic and activities medication on the way to hide particular parts of the orthopaedic self-discipline the place the remedy may be better and/or replaced by way of the developments in molecular medication. developments in molecular biology, which surround the examine of the genetic foundation of sickness, have produced new diagnostic equipment and drug treatments for genetic ailments and purchased problems. the expansion within the knowing of human genetics has additionally ended in the initiation of many human gene remedy experiments. even though many licensed healing scientific trials utilizing this new expertise were played within the final ten years, the 1st medical trial utilizing this expertise within the region of orthopaedics was once played on the collage of Pittsburgh.
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Extra info for Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine
Growth factors as therapeutic agents. J Bone Joint Surg 78-AI272-86. S.. , Marconi, P, Glorioso, J, and Huard, J 1998. The development of approaches to improve viral gene delivery to mature skeletal muscle. Neuromus Disorders 8:135-48. van Deutekom, JCT, Hoffman. P, and Huard, 1. 1998. Muscle maturation: implications for gene therapy. Mol Med Today 4(5):214-20. 40 1. G. 1996. Condensation of plasmid DNA with polylysine improves liposome mediated gene transfer into established and primary muscle cells.
This ex vivo technique, which combines cell and gene therapy, may be advantageous for the musculoskeletal system because the cells can be used as a reservoir of secreting molecules as well as a source as of exogeneous cells capable of participating in the healing process. In fact, the use of pluripotent muscle derived stem cells in our ex vivo approach using musclebased tissue engineering (see review in Chapter 11) may become very attractive for the healing of the musculoskeletal system. 3). It has been shown that muscle cells can be successfully transduced in vitro and in vivo using intramuscular inoculation of replication defective Ad, RV and HSV carrying luciferase and ~-galactosidase as reporter genes (Acsadi et al.
Karpati, G. and Worton, RG1992. Myoblast transfer in DMD: problems and interpretation of efficiency. Muscle Nerve 15:1209. C, and Huard, 1. 1998. Development of approaches to improve the healing following muscle contusion. Cell Transpl 7(6):58598. C, and Huard, 1. 1998. Biologic intervention in muscle healing and regeneration. Sports Med Arthrosc Rev 6:95-102. P 1994. Very efficient myoblast allotransplantation in mice under FK506 immunosuppression. Muscle Nerve 17:1407-15. 1996. A new adenoviral vector: replacement of all viral coding sequences with 28kb of DNA independently expressing both full length dystrophin and betagalactosidase.