By Louis J. Guillette, D. Andrew Crain
Addresses many points of endocrine disruption by means of environmental encountered poisonous ingredients. preliminary chapters offer crucial historical past info while later chapters deal with particular elements of endocrine disrupting contaminants (EDC)
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Extra resources for Environmental Endocrine Disruptors
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Most likely, because of the expense of breaking carbon bonds and because many of the active hormones are produced by irreversible reactions, steroids are not typically degraded and recycled but are rather targeted for excretion. This targeting involves the attachment of SO4 and sugar moieties to oxygens on carbon-3 and carbon-17. The sulfations and glucoronidations, respectively, are regulated by sulfases and glucoronidases in the liver and kidney. Once sulfated and glucoronidated, steroids become hydrophilic, cannot traverse lipid 32 COMPARATIVE ENDOCRINOLOGY membranes in target tissues, and can be filtered by the blood and excreted in the urine.