Download Environmental Endocrine Disruptors by Louis J. Guillette, D. Andrew Crain PDF

By Louis J. Guillette, D. Andrew Crain

Addresses many points of endocrine disruption by means of environmental encountered poisonous ingredients. preliminary chapters offer crucial historical past info while later chapters deal with particular elements of endocrine disrupting contaminants (EDC)

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Extra resources for Environmental Endocrine Disruptors

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Jr. (1998b). Cellular bioavailability of natural hormones and environmental contaminants as a function of serum and cytosolic binding factors. Toxicol. Industrial Health 14:261–273. R. (1996). Estrogenic activity of chlordecone, o,p′DDT and o,p′-DDE in juvenile rainbow trout: Induction of vitellogensis and interaction with hepatic estrogen binding sites. Aquatic Toxicol. 36: 31–52. J. (1976). A cytoplasmic estrone-specific binding protein (EIBP) in hen liver. Fed. Proc. 35:1366. A. (1995). Endocrinology and Metabolism, McGraw-Hill, New York.

1996b). In vivo modula tion of 17-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss). Toxicol. Appl. Pharmacol. 137(2): 210–218. A. (1996b). A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens. Environ. Health Perspec. 104(5): 544–548. C. (1996). Actions of oxytocin and vasopressin on oestrogen-induced electromyographic activity recorded from the uterus and oviduct of anoestrous ewes. Reprod. Fert.

Most likely, because of the expense of breaking carbon bonds and because many of the active hormones are produced by irreversible reactions, steroids are not typically degraded and recycled but are rather targeted for excretion. This targeting involves the attachment of SO4 and sugar moieties to oxygens on carbon-3 and carbon-17. The sulfations and glucoronidations, respectively, are regulated by sulfases and glucoronidases in the liver and kidney. Once sulfated and glucoronidated, steroids become hydrophilic, cannot traverse lipid 32 COMPARATIVE ENDOCRINOLOGY membranes in target tissues, and can be filtered by the blood and excreted in the urine.

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