By I. Leusen, J. Weyne (auth.), Professor Dr. Marianne E. Schläfke, Dr. Wolf R. See M.A., Professor Dr. Hans-Peter Koepchen (eds.)
This quantity comprises the papers awarded on the symposion on critical Neurone setting and the regulate platforms of respiring and circulate held at Bochum, October 5-7,1981 in honour of Prof. Dr. Dr. h.c. Hans H. Loeschcke, who retired in March 1981. His discovery of ventral medullary substrates forming a necessary force for the ventilatory in addition to for circulatory keep watch over platforms, and the elaboration of this idea over the past 25 years have profoundly prompted the thoughts during this box. In an age of continuing specializa tion on partial mechanisms, his technique has continuously emphasised the integrative features of the keep watch over structures, specifically the function of the breathing keep watch over approach for the ionic homeostasis of the mind and the shut interrelation among neuronal breathing and cardiovascular keep watch over. This basic goal implies the mix of physico chemical and neurophysiological methods in addition to the research of peripheral functionality of breathing and flow, issues that are frequently dealt with individually in accordance with the several methods.
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This quantity includes the papers provided on the symposion on valuable Neurone setting and the keep an eye on structures of respiring and move held at Bochum, October 5-7,1981 in honour of Prof. Dr. Dr. h. c. Hans H. Loeschcke, who retired in March 1981. His discovery of ventral medullary substrates forming a necessary force for the ventilatory in addition to for circulatory keep watch over platforms, and the elaboration of this idea over the last 25 years have profoundly encouraged the thoughts during this box.
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Extra info for Central Neurone Environment and the Control Systems of Breathing and Circulation
During lung passage time (T = 700 ms) CO 2 hydration is catalyzed in the plasma too (extracellular catalyzing factor CF between 1 and 100). After leaving the lung CF changes to 1. 3 kPa) instantaneously, when blood reaches the lung. 375. Figure 5 shows the influence of different values of CF on the pH and pC0 2 time functions. If the CO 2 48 A. Luttmann and K. 8 54 I I I I I CF = 1 ~ : ; -20 7 .. 40 738 5 Iung passage 15 25 .. t[sl Fig. S. Calculated pC0 2 and pH time courses in blood during and after lung transit.
In: Piiper J, Scheid P (eds) Gas exchange function of normal and diseased lungs. Karger, Basel, p 193 Middendorf T, Loeschcke HH (1974) Approximative Berechnung der Pufferbase, einer Titrationsgeraden fUr Proteine und der C02-Dissoziationskurve des Gehirngewebes. Pfliigers Arch 349: 1-8 Investigation of the IonaI and Gaseous Exchange 41 Miickenhoff K (1973) Die Berechnung des Siiuren-Basen-Status des menschlichen Vollblutes mit Hilfe eines numerischen Verfahrens. Diss Ruhr-Univ Bochum, Abt BioI Miickenhoff K, Luttmann A (1980) Ein flammenfotometrisches Verfahren mit hoher Auflosung zur Bestimmung der Kationenkonzentration im Blut.
Miickenhoff 46 Table 1. Influence of lactate, acetate and ammonia on the time for reaching 90% of the total change of the plasma H+ ion concentration (T 90) in a thin film of human blood after a stepwise change of the Co. 08 in 0. 2 and vice versa (mean values from 6 to 8 experiments) Co. 28 02 • • ~ ~ lOs I--t Fig. 3. riginal recordings of the pCo. 2' Gas in front of the blood film was changed from an 0. 2 CO2 mixture to a N2 - 0. 2 mixture both having the same pCo. 2 In another type of experiment an acid base disturbance was induced by changing the p02 (Christiansen - Douglas - Haldane effect).