By Jeffrey Laurence (auth.), Jean-Marie Andrieu, Wei Lu (eds.)
In the earlier decade, the worldwide efforts within the keep an eye on of HIV sickness have been primarily targeting the hunt for anti-retroviral brokers. thus far, anti-HIV remedies were proven to be disappointing due to fast improvement of drug-resistant mutant versions. regardless of this difficulty within the healing struggle opposed to HIV an infection, antiviral examine can be actively pursued. besides the fact that, failure of antiviral remedy shows that different avenues of study can be speedily explored with an analogous strength. during this surroundings, remarkable advances were lately made within the dissection and figuring out of the viro-immunological approaches governing the revolutionary destruction of lymphoid organs linked to AIDS boost ment, and HIV-induced activation and apoptosis were pointed out as key phenomena of the immune procedure destruction. This publication assembles the newest advances on uncomplicated and scientific elements ofT-cell activationiapoptosis in HIV an infection and their implications for immunotherapy. those facts have been offered at a global symposium hung on July 11-12, 1994, in Paris. The ebook is partitioned into 21 chapters overlaying 4 complete fields: 1) T-celllmacrophage activation and HIV an infection; 2) Apoptosis and viropathogenesis of hello V illness; three) Apop tosis and immunopathogenesis ofHIV sickness; four) Mediators ofT-cell activationiapoptosis and healing purposes. we are hoping that this e-book will support the readers in figuring out fresh advances within the viro-immunopathogenesis of hello V sickness in addition to the rationales for power immune cell-targeted healing interventions.
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Extra info for Cell Activation and Apoptosis in HIV Infection: Implications for Pathogenesis and Therapy
HIV-l infection of the SCID-hu mouse: An animal model for virus pathogenesis. Nature 363:732-36. 24. Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune 1M, Kaneshima H. 1993. HIV induces thymus depletion in vivo. Nature 363:728-36. 25. Jamieson BD, Aldrovandi GM, Planelles V, Jowett IBM, Gao L, Bloch LM, Chen ISY, Zack JA. 1994. Requirement ofHIV-l neJfor in vivo replication and pathogenesis. J. 68:3478-85. 26. Stanley SK, McCune 1M, Kaneshima H, Justement JS, Sullivan M, Boone E, Baseler M, Adelsberger J, Bonyhadi M, Orenstein J, Fox CH, Fauci AS.
R ..... gog Figure 1. Major reverse transcription in the cytoplasm and nucleus of HIV-I infected cells. After initiation of reverse transcription, two template switches result in a full length cDNA containing complete plus and minus strand DNA. After transport to the nucleus some linear molecules undergo LTR recombination and intra-molecular ligation resulting in the production of 1 LTR and 2 LTR circles respectively. Primers used for the specific amplification of the various cDNA forms are indicated.
Thus, we have attempted to examine the influence of exogenous antigens (as introduced during vaccination with bacterial antigens) on virus burden. , 1990) and, as a consequence, pneumococcal polysaccharide vaccine is recommended for adults with asymptomatic or symptomatic HIV-l infection. A series of asymptomatic HIV-l seropositive individuals who currently were not on any anti-retroviral therapy were vaccinated with pnuemococcal polysaccharides (Pneumovax). Plasma from vaccinated individuals was collected prior to and at various intervals after vaccination.