Download Biology - Chemistry Interface A Tribute to Koji Nakanishi by Raymond Cooper, John K. Snyder PDF

By Raymond Cooper, John K. Snyder

A tribute to the pioneering medical paintings of Professor Koji Nakanishi, whose reviews of ordinary items have effaced the various traditional limitations among biology and chemistry. It discusses an array of chromatographic separation tools and backbone of buildings on a microscale, analyzes bioassay-directed fractionation and different technique of separating biologically energetic compounds from vegetation and different resources, covers very important enzymes remoted from marine organisms akin to algae, and extra.

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Cerevisiae, and the combinations with 18 were the most effective against P. ovale [44]. In addition, 16 was also combined with other antifungal agents, such as amphotericin B. This combination was investigated since amphotericin B is also known to damage the plasma membrane by interacting with sterols [41] in fungal cells [40]. However, 16 did not enhance the antifungal activity of amphotericin B against C. albicans and S. cerevisiae; in fact, its antifungal activity was somewhat antagonized by 16, as shown in Table 3.

This glucose-induced medium acidification was inhibited by 3, as illustrated in Fig. 4. The inhibition was presumably caused by inhibition of Hϩ-ATPase. In support of this conclusion, 3 was also found to inhibit the isolated Hϩ-ATPase of S. cerevisiae. Therefore, it is possible that the potent antifungal activity of 3 is, at least in part, due to its inhibition of the plasma membrane Hϩ-ATPase. Interestingly, the inhibitory action of 3 on the glucose-induced acidification of the medium was strongly suppressed by Ca 2ϩ, but only weakly by Mg2ϩ.

F. ), Academic Press, New York, p. 353 (1983). J. O. Kokwaro, Medicinal Plants of East Africa, East African Literature Bureau, Nairobi, Kenya, (1976). J. M. Watt and M. G. Breyer-Brandwick, The Medicinal and Poisonous Plants of Southern and Eastern Africa, E. & S. Livingstone, London, (1962). D. E. Champagne, O. Koul, M. B. Isman, G. G. E. Scudder, and G. H. N. Towers, Phytochemistry, 31: 377 (1992). H. Rembold, in Focus on Phytochemical Pesticides. Vol. 1. The Neem Tree (M. , p. 47 (1988). H. Rembold, in Insecticides of Plant Origin (J.

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