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Extra resources for Antiepileptic drugs: combination therapy and interactions
There is unlikely to be a role for screening for these. There are, however, serious adverse events with AED use that may benefit from pharmacogenetic screening. Pharmacogenetic screening of serious adverse events that result from drug metabolites is potentially a powerful application. , 1998). , 1998).
150 years of pharmacovigilance. Lancet 1998a; 351: 1200–1201. Routledge P. In Detection of New Adverse Reactions, 4th edn. M. D. B. Stephens, J. C. C. Talbot, P. A. Routledge, eds. , 1998b. Seymour RM, Routledge PA. Important drug–drug interactions in the elderly. Drug Ageing 1998; 6: 485–494. Shorr RI, Ray WA, Daugherty JR, et al. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993; 153(14): 1665–1670.
Benzodiazepines are specific modulators of GABAA receptors and act at GABAA receptors that contain an ␣1, ␣2, ␣3 or ␣5 subunit in combination with a ␥ subunit (Mehta and Ticku, 1999). , 2000). This is due perhaps to the varied distribution of these receptors in the brain. , 2000). , 2000). More selective ligands could thus result in benzodiazepine agonists that have less sedative effect and greater anticonvulsant potential. Importantly, single amino acid substitutions rendering certain subunits insensitive to benzodiazepines can thus radically alter the profile of these drugs.