By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play a tremendous position in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step approach: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated by way of numerous diversified hormones. The sodium channels additionally play an important position in a couple of illness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and sensible variety presents the 1st in-depth alternate of principles relating those sodium channels, their law and involvement in common and pathophysiological events. Key positive aspects * Summarizes present nation of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal rules of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents rules on sodium channels and illness
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Extra resources for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
Fuller, C. , Berdiev, B. , Shlyonsky, V. , Ismailov, I. , and Benos, D. J. (1997). Point mutations in abENaC regulate channel gating, ion selectivity and sensitivity to amiloride. Biophys. J. 72, 1622-1632. , Hyman, B. , and Corey, D. P. (1997). BNaCl and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc. Natl. Acad. Sci. U S A . 94,1459-1464. , and Palmer, L. (1997). Epithelial sodium channels: Function, structure and regulation.
Ausiello, D. , Fuller, C. , Benos, D. , and Ismailov, I. I. (1996). Regulation of epithelial sodium channels by short actin filaments. J . Biof. Chem. 271, 17704-17710. Bradford, A. , Berdiev, B. , Ismailov, I. , Fuller, C. , and Benos, D. J . (1997). Functional effects of mutations in the membrane spanning regions of the a-subunit of the amiloridesensitive Na' channel (ENaC). Physiologist 40, A-7 (abstr. 6). , Sorscher, E. , Ausiello, D. , and Benos, D. J. (1989). Immunocytochemical localization of Na' channels in rat kidney medulla.
And Sasaki, S. (1996). Liddle disease caused by missense mutation of p subunit of the epithelial Nat channel gene. J. Clin. Invesr. 97, 1780-1784. , Alley, C. , Sorscher, E. , Brinkley, B. , and Benos, D. J. (1989). Immunochemical localization of amiloride-sensitive sodium channels in sodium transporting epithelia. J. Cell Sci. 93, 349-362. , and Lazdunski, M. (1995a). Functional degenerin-containing chimeras identify residues essential for arniloride-sensitive Na+ channel function. J. Biol. Chem.