By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)
After 3 volumes on adenoviruses in 1995 the prior years have noticeable quick growth within the box of adenovirus learn. furthermore, adenoviruses have attracted huge curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity offers with the immune process, oncogenesis and gene remedy.
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Extra resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy
30 34 35 40 40 45 E3119K-Mediated Inhibition of Antigen Presentation by ER Retention and ER Retrieval . . . . . . . . . . . . . . . 5K Complex: Rerouting of Plasma Membrane Receptors to Lysosomes for Degradation . 57 5 Transport of a Novel Ad E3-Encoded Lymphocyte-Binding Factor to a Site of Proteolytic Processing Required for Secretion . . . . 6 E3 Transmembrane Proteins with Unknown Functions Containing Putative Trafficking Motifs in Their Cytoplasmic Tails .
1997; Tomko et al. 1997; Amberg et al. 2000; Nemerow 2000), and this initial step is followed by internalization of virions into an endosomal compartment (Shenk 1996). During this process, the step- Immune Evasion by Adenovirus E3 Proteins 31 wise release of virion proteins destabilizes the capsid, which penetrates the lipid bilayer of the endosomes, reaches the cytoplasm, and migrates along microtubules to the nuclear pore complex (Suomalainen et al. 1999). After disassembly of the capsid, the DNA genome and associated proteins are imported into the nucleus, where early gene transcription starts (Russell 2000; Whittaker et al.
After disassembly of the capsid, the DNA genome and associated proteins are imported into the nucleus, where early gene transcription starts (Russell 2000; Whittaker et al. 2000). The early Ad proteins induce cell-cycle progression without triggering the intrinsic apoptosis pathways, prepare the cell for DNA replication, and provide multiple protective measures against the attack by the immune system. In the late phase of infection, mainly structural proteins are being synthesized, and new virions are assembled in the nucleus.