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By Privatdozentin Dr. med. Ursula Creutzig (auth.), Privatdozentin Dr. med. Ursula Creutzig, Professor Dr. med. Jörg Ritter, Professor Dr. med. Günther Schellong (eds.)

The result of remedy for youth acute myelogenous leukemia (AML) have stronger significantly over the last ten years. This development was once established via the 2 consecutive multicenter stories, AML-BFM-78 and -83, within which virtually exact prolonged multi drug regimes of che­ motherapy have been administered for 8 weeks and up by means of years upkeep. the most distinction within the moment learn used to be the addition of an eight-day in depth in­ duction path. because of this new aspect, the relapse expense used to be diminished considerably. one other results of the BFM-83 research used to be the definition of 2 possibility teams at the foundation of standardized remedy, which has result in a risk-adapted remedy approach within the 3rd ongoing trial, AML-BFM- 87. This development was once simply attainable due to the coop­ eration of pediatricians, physicians, radiotherapists, statisti­ cians, and particularly the employees on the hospitals and reference laboratories. therefore, we wish to thank every person who has been fascinated with those stories and desire that they are going to be additional inspired to enhance therapy techniques for AML in teenagers. The coordination, enforcement, and analyses of the stud­ ies do not have been attainable with out the monetary sup­ port of the Federal Ministry for learn and expertise of the FRG. we're thankful for the beneficiant contributions assisting this booklet from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 creation . . . . .. . . . . . . . . . . . . . . .. . . . 1 .

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A Probability of EFS duration in patients with FAB Ml in AML-BFM-78 vs. AML-BFM-83. b Same for EFI duration FAB M3. Out of a total of 11 patients with acute promyelocytic leuke- mia, two suffered ED from intracranial hemorrhage, one from ulcer bleeding and one from sepsis. Of the two children who died in CCR, one died after six weeks from the sequelae of anthracycline-induced cardiotoxicity, the other from undetected tuberculosis after eight months. There was only one relapse after six months. Four patients remained in CCR, for 39, 54, 92, and 116 months respectively (Table 19).

B ~ II.. /.. •........... 0 ........... 0 2 GIRLS BOYS N N -- 3 4 146 176 5 6 7 B 9 10 YEARS 5B IN CCR 76 IN CCR Fig. 19. Probability of EFS duration, girls vs. boys. 1 Influence of Sex in the FAB Types Table 20 shows the results by FAB types. 01). The difference in EFS (Fig. 13). In the FAB types M2 and M5, the EFS and BFI curves show no differences between girls and boys. Although there was a higher relapse rate in boys with FAB M4 (Fig. 18). B ~ II.. 6 ..... , .... /...........................................................................

J 0 ::s = a. W 0. ~ (") i 0 .... &l ~. ~ ::s QQ 9' 0. 2. ::s Ci! -= ~ ~ I» "t:I 0 .... [- ::s 0 g: ~ 0 (") 34 Results Table 14. 02 there is a weak association with eosinophilia and with an absence of extramedullary organ involvement. With hepatomegaly, the proportion of POX positive blasts required for association tends to be lower, whereas a high proportion of POX positive blasts is associated with eosinophilia in the BM. An increased proportion of blasts on day 15 correlates negatively with eosinophilia, and positively with hyperleukocytosis.

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